Melanoma Oncolytic Immunotherapy:
An Evolving Therapeutic Landscape

Treatment for patients with melanoma has been revolutionized by the integration of new immunotherapeutic strategies. Although anti–programmed cell death 1 (PD1) checkpoint inhibitors have greatly improved survival outcomes for many patients with advanced melanoma, effective treatment approaches are greatly needed in the setting of anti-PD1–failed melanoma. In this poor-prognosis patient population, emerging oncolytic virus immunotherapies may offer great promise. This interactive program provides updates on the evolving landscape of oncolytic viruses and summarizes the rationale for their use in challenging treatment settings. Faculty review the latest clinical evidence and discuss the potential positioning of emerging oncolytic viruses within existing treatment paradigms for patients with advanced melanoma.

ACTIVITY CHAIR:

Michael Ka Keu Wong
MD, PhD, FRCPC

Professor, Melanoma and Cutaneous Malignancies
Medical Executive – MD Anderson Cancer Network
Houston, TX

FACULTY:

Anna Pavlick
BSN, MSc, DO, MBA

Weill Cornell Medicine
New York, NY

FACULTY:

Douglas B. Johnson
MD, MSCI

Vanderbilt University School of Medicine
Nashville, TN

Learning Objectives

Upon successful completion of this activity, participants should be better able to:

• Review the pathophysiology of advanced melanoma, including consensus definitions for determining anti–programmed cell death 1 (PD1) protein resistance.
• Describe the mechanism of action of oncolytic virus technology and the rationale for its use as a treatment for anti-PD1–failed melanoma.
• Summarize the latest clinical evidence on emerging oncolytic viruses for the treatment of patients with anti-PD1–failed melanoma.
• Assess the potential positioning of oncolytic viruses within existing treatment paradigms for patients with anti-PD1–failed melanoma.

Target Audience

The intended audience for this activity includes oncologists and other healthcare professionals involved in the management of patients with melanoma.

Accreditation/Designation of Credit

In support of improving patient care, Vindico Medical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.Vindico Medical Education designates this live activity for a maximum of 1.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Vindico Medical Education adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers, or others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest will be mitigated prior to the commencement of the activity.